丅sa007箱子密码锁怎么打开开

来源：蜘蛛抓取(WebSpider) 时间：2015-02-08 06:03 标签： 打开密码锁
英语翻译Impact of Nucleoside Reverse Transcriptase Inhibitors on Mitochondria in HIV-1Infected Children Receiving HAART.Saitoh A,Fenton T,Alvero C,Fletcher CV,Spector SA.Division of Infectious Diseases,Department of Pediatrics,University ofCalifo_作业帮
英语翻译Impact of Nucleoside Reverse Transcriptase Inhibitors on Mitochondria in HIV-1Infected Children Receiving HAART.Saitoh A,Fenton T,Alvero C,Fletcher CV,Spector SA.Division of Infectious Diseases,Department of Pediatrics,University ofCalifo
英语翻译Impact of Nucleoside Reverse Transcriptase Inhibitors on Mitochondria in HIV-1Infected Children Receiving HAART.Saitoh A,Fenton T,Alvero C,Fletcher CV,Spector SA.Division of Infectious Diseases,Department of Pediatrics,University ofCalifornia San Diego,La Jolla,CA,Center for Molecular Genetics and Center for AIDS Research,Center for Biostatistics in AIDS Research,Harvard School ofPublic Health,Boston,MA,Department of Clinical Pharmacy,University ofColorado Health Science Center,Denver,CO.Background:Mitochondrial toxicity induced by nucleoside reverse transcriptaseinhibitors (NRTI) has been reported to be responsible for various adverseeffects.The relative impact of NRTI on mitochondria of HIV-1 infected childrenreceiving highly active antiretroviral therapy (HAART) is unknown.Methods:Mitochondrial DNA (mtDNA) levels were quantified longitudinally from peripheralblood mononuclear cells (PBMC) in 31 HIV-1-infected children from PACTG 382receiving HAART including nelfinavir,efavirenz,and different NRTI withundetectable plasma HIV-1 RNA >2 years.Results:The median mtDNA levels in PBMC increased from 137 copies/cell at baseline to 179 copies/cell at week 48 (P =0.01) and 198 copies/cell at week 104 (P < 0.001).Before initiation of HAART,children who received regimens containing didanosine had persistently lower mtDNAlevels compared to those in children without didanosine (106 vs.140 copies/cell,P = 0.008).During HAART,the median mtDNA increase from baseline to week 104 wasthe lowest in children who received regimens containing didanosine (+26copies/cell) compared to other regimens (+79 copies/cell) (P = 0.02).Amultivariate analysis also demonstrated that the use of ddI during HAART was the only NRTI associated with the change in mtDNA levels (P = 0.007).Conclusion:Children receiving didanosine containing antiretroviral regimens have the lowest mtDNA in PBMC and may be at greater risk for long-term adverse effects due tomitochondrial toxicity.This may be of particular importance in resource-limited countries where didanosine is widely used for treatment of HIV-infected children.PMID: [PubMed - as supplied by publisher]
核苷相反Transcriptase 抗化剂的冲击对线粒体在HIV-1 被传染的孩子接受HAART .Saitoh A,Fenton T,Alvero C,Fletcher CV,SA Spector .传染病分部,小儿科,大学的部门 加利福尼亚圣迭戈,La Jolla 、分子遗传学的加州、中心和中心为 爱滋病研究,生物统计学的中心在爱滋病研究,哈佛学校 公共卫生,波士顿,麻省,临床药房,大学的部门 科罗拉多健康科学中心,丹佛,CO .背景:线粒体毒力被核苷相反transcriptase 导致 抗化剂(NRTI) 被报告负责对各种各样有害 作用.NRTI 的相对冲击对HIV-1 线粒体传染了孩子 接受高度活跃antiretroviral 疗法(HAART) 是未知的.方法:线粒体DNA (mtDNA) 水平纵向地被定量了从外围设备 血液单核细胞(PBMC) 在31 HIV 1 传染了孩子从PACTG 382 接受HAART 包括nelfinavir 、efavirenz,和另外NRTI 与 探测不到的血浆HIV-1 核糖核酸>2 岁月.结果:中点mtDNA 水平在PBMC 增加从137 copies/cell 在基础线对179 copies/cell 在星期48 (P = 0.01) 和198 copies/cell 在星期104 (P < 0.001).在HAART 的启蒙之前,接受养生之道包含didanosine 的孩子有坚持地更低的mtDNA 水平与那些比较对于儿童没有didanosine (106 对.140 copies/cell,P = 0.008) .在HAART 期间,中间mtDNA 增量从基础线到星期104 是 最低对于接受养生之道包含didanosine 的儿童(+26 copies/cell) 与其它养生之道比较(+79 copies/cell) (P = 0.02) .A 多维分布的分析并且显示出,对ddI 的用途在HAART 期间是 唯一NRTI 联系了变化在mtDNA 水平上(P = 0.007) .结论:孩子接受didanosine 包含antiretroviral 养生之道有最低 mtDNA 在PBMC,也许是在更加巨大的风险为长期不利影响由于 线粒体毒力.这也许是特别重要在资源有限 didanosine 广泛被应用为HIV 被传染的孩子的治疗的国家.PMID: [ PubMed - 依照按出版者供应

我要回帖

更多关于 打开密码锁 的文章

 

随机推荐