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Copyright &. All Rights Reserved .&&闽ICP备号程亮博士介绍-苏州大学功能纳米与软物质研究院-刘庄教授课题组
Nanomedicine Group
邮箱: zliu@
电话: 86-512-
传真: 86-512-
苏州大学功能纳米与软物质研究院
江苏省苏州市工业园区仁爱路199号，910楼401(517)室
86-512-，Fax: 86-512-
学习工作经历：
&&&&2015年8月至今，美国威斯康辛大学麦迪逊分校，访问学者
&&&&2014年7月至今，苏大学功能纳米与软物质研究院，副教授
&&&&2012年8月至2014年7月，苏大学功能纳米与软物质研究院，讲师
&&&&2012年6月在苏州大学功能纳米与软物质研究院获得博士学位
&&&&2009年6月在安徽师范大学获得无机化学硕士学位
&&&&2006年6月在安徽工程大学获得应用化学学士学位
研究方向与学术成果：
&&&&从2008年起在国际学术期刊共发表学术论文共60余篇，其中第一作者或通讯作者论文26篇，部分发表在Chem. Rev. Angew Cheme, Adv. Mater., JACS, ACS Nano, Adv. Funct. Mater., Biomaterials, Nano Res., Nanoscale上，文章发表至今被引用1800次，H-index因子为21。获得国家自然科学青年基金一项，江苏省自然科学青年基金一项，中国博士后特别资助一项，中国博士后基金一项，江苏省博士后基金一项和高校省级重点实验室开放课题一项。目前的研究方向主要集中在功能性复合纳米材料在生物医学成像、药物输送和癌症综合治疗等方面的应用。
获得奖项：
&&&&2014年获得苏州大学考核优秀工作者
&&&&2013年获得苏州大学优秀博士论文
&&&&2013年获得第三届中加纳米论文优秀墙报奖
&&&&2012年获得苏州大学优秀毕业生，苏州大学学术标兵，朱敬文特别奖学金
&&&&2012年获得第七届中美纳米论坛墙报奖银奖
&&&&2011年获得朱敬文奖学金，FUNSOM科研成果奖，苏州大学优博选题重点资助，江苏省研究生创新计划资助
&&&&2010年获得苏州大学优秀研究生
已发表论文：
[69]Gong, Q.F+, Cheng, L+, Liu, C.H., Zhang, M., Feng, Q.L., Ye, H.L., Zeng, M., Xie, L.M., Liu, Z*, Li, Y.G.*, “Ultrathin MoS2(1–x)Se2x Alloy Nanoflakes For Electrocatalytic Hydrogen Evolution Reaction” ACS Catal., 13-2219.
[68] Zhu, W.W, Liu, K., Sun, X.Q, Wang, X., Li, Y.G, Cheng, L.*, Liu, Z., “Mn2+-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance”, ACS Appl. Mater. Interfaces, 575-11582.
[67] Juan, J.X., Cheng, L.*, Shi, M., Liu, Z, Mao, X.L.*, “Poly-(allylamine hydrochloride) but not poly(acrylic acid)-coated upconversion nanoparticles induce autophagy and apoptosis in human blood cancer cells” J. Mater. Chem. B, 2015, DOI: 10.646E.
[66] Qian, X.X., Shen, S.D. Liu, T., Cheng, L.*, Liu, Z., “Two-dimensional TiS2 nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy” Nanoscale, 80-6387.
[65] Cheng, L.; Wang, C.; Feng, L.Z.; Yang, K.; Liu, Z.*, Functional Nanomaterials for Phototherapies of Cancer. Chem. Rev., , .
[64] Cheng, L.; Huang, W.; Gong, Q.; Liu, C.; Liu, Z.*; Li, Y.*; Dai, H., Ultrathin WS2 Nanoflakes as a High-Performance Electrocatalyst for the Hydrogen Evolution Reaction. Angewandte Chemie International Edition 2014, 53 , (Back cover, hot article)
[63] Cheng, L.*; Gong, H.; Zhu, W.; Liu, J.; Wang, X.; Liu, G*.; Liu, Z*., PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy. Biomaterials,44-9852.
[62] Song, X.; Gong, H.; Liu, T.; Cheng, L.*; Wang, C.; Sun, X.; Liang, C.; Liu, Z.*, J-Aggregates of Organic Dye Molecules Complexed with Iron Oxide Nanoparticles for Imaging-Guided Photothermal Therapy Under 915-nm Light. Small 62-4370.
[61] Wang, X.; Liu, K.; Yang, G.; Cheng, L.*; He, L.; Liu, Y.; Li, Y.; Guo, L.; Liu, Z.*, Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing. Nanoscale 98-9205;
[60]Shen, J.; Li, K.; Cheng, L.*; Liu, Z.; Lee, S.-T.; Liu, J.*, Specific Detection and Simultaneously Localized Photothermal Treatment of Cancer Cells Using Layer-by-Layer Assembled Multifunctional Nanoparticles. ACS Applied Materials & Interfaces 2014, 6 , ;
[59] Shi, M+.; Cheng, L+.; Zhang, Z.; Liu, Z.; Mao, X.* Ferroferric oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin 1/Bcl-2/VPS34 complex, 2014, In press (equal contribution)
[58] Tian, T.; Shi, X.; Cheng, L.; Luo, Y.; Dong, Z.; Gong, H.; Xu, L.; Zhong, Z.; Peng, R.*; Liu, Z.*, Graphene-Based Nanocomposite As an Effective, Multifunctional, and Recyclable Antibacterial Agent. ACS Applied Materials & Interfaces 2014, 6 , ;
[57] Wang, C.; Sun, X.; Cheng, L.; Yin, S.; Yang, G.; Li, Y.; Liu, Z.*, Multifunctional Theranostic Red Blood Cells For Magnetic-Field-Enhanced in vivo Combination Therapy of Cancer. Advanced Materials 2014, 26 , ;
[56] Chen, Q.; Wang, C.; Cheng, L.; He, W.; Cheng, Z.; Liu, Z.*, Protein modified upconversion nanoparticles for imaging-guided combined photothermal and photodynamic therapy. Biomaterials 2014, 35 , ;
[55] Liu, T.; Wang, C.; Gu, X.; Gong, H.; Cheng, L.; Shi, X.; Feng, L.; Sun, B.; Liu, Z.*, Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer. Advanced Materials 33-3440.
[54] Fang, S.; Wang, C.; Xiang, J.; Cheng, L.; Song, X. J.; Xu, L.G.; Peng, R.; Liu, Z. Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells, Nano Res.,27-1336.
[53] Cheng, L.; Liu, J.J.; Gu, X.; Gong, H., Shi, X.Z.; Liu, T., Wang, C., Wang, X.Y., Liu, G.; Xing, H.Y.; Bu, W.B.; Sun, B.Q.; Liu, Z*., PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT / photoacoustic imaging guided photothermal therapy. Adv. Mater., 86-1893,(inside cover).
[52] Cheng, L.; Liu, J.J.; Gu, X.; Gong, H., Shi, X.Z.; Liu, T., Wang, C., Wang, X.Y., Liu, G.; Xing, H.Y.; Bu, W.B.; Sun, B.Q.; Liu, Z*., PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT / photoacoustic imaging guided photothermal therapy. Adv. Mater., 2013, DOI: 10.1002/adma..
[51] Cheng, L.; He, W.; Gong, H.; Wang, C.; Chen, Q.; Cheng, Z.; Liu, Z., PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy. Adv. Funct. Mater., 2/adfm..
[50] Cheng, L.; Wang, C.; Ma, X.; Wang, Q.; Cheng, Y.; Wang, H.; Li, Y.; Liu, Z*., Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem Cell Therapy under Remote Magnetic Control. Adv. Funct. Mater. 2-280.
[49] Cheng, L; Wang, C.; Liu, Z*., Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy. Nanoscale -37.
[48] Liu, Y.; Yang, K.; Cheng, L*.; Zhu, J.; Ma, X.; Xu, H.; Li, Y.; Guo, L.; Gu, H.; Liu, Z*., PEGylated FePt@Fe2O3 core-shell magnetic nanoparticles: Potential theranostic applications and in vivo toxicity studies. Nanomedicine: Nanotechnology, Biology and Medicine ), .
[47] Yin, S.; Li, Z.; Cheng, L* Wang, C.; Liu, Y.; Chen, Q.; Gong, H.; Guo, L.; Li, Y.; Liu, Z., Magnetic PEGylated Pt3Co nanoparticles as a novel MR contrast agent: in vivo MR imaging and long-term toxicity study. Nanoscale 2013, DOI: 10.212
[46] Gong, H.; Cheng, L.; Xiang, J.; Xu, H.; Feng, L.; Shi, X.; Liu, Z*., Near-Infrared Absorbing Polymeric Nanoparticles as a Versatile Drug Carrier for Cancer Combination Therapy. Adv. Funct. Mater., 2013, DOI: 10.1002/adfm.
[45] Wang, C.; Cheng, L.; Ma, X.; Wang, X.; Liu, Y.; Deng, Z.; Li, Y., Liu Z*., Imaging-guided pH Sensitive Photodynamic Therapy using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light. Adv. Fuct. Mater. 2013, DOI: 10.1002/adfm.
[44] Wang, C.; Cheng, L.; Liu, Z*., Upconversion nanoparticles for photodynamic therapy and other cancer therapeutics. Theranostics 2013, DOI:10.7150/thno.5284.
[43] Xu, L.; Cheng, L.; Wang, C.; Peng, R*.; Liu, Z*., Conjugated polymers for photothermal therapy of cancer. Poly. Chem. 2014, DOI: 10.196H.
[42] He, W.; Cheng, L.; Zhang, L.; Liu, Z*.; Cheng, Z*.; Zhu, X., A versatile Fe3O4 based platform via iron-catalyzed AGET ATRP: towards various multifunctional nanomaterials. Polymer Chemistry 2014;
[41] He, W.; Cheng, L.; Zhang, L.; Liu, Z*.; Cheng, Z*.; Zhu, X., Facile Fabrication of Biocompatible and Tunable Multifunctional Nanomaterials via Iron-Mediated Atom Transfer Radical Polymerization with Activators Generated by Electron Transfer. ACS Applied Materials & Interfaces ), .
[40] Li, Z.; Yin, S.; Cheng, L.; Yang, K.; Li, Y.; Liu, Z*., Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer. Advanced Functional Materials 2/adfm., n/a-n/a;
[39] Li, Z.; Wang, C.; Cheng, L.; Gong, H.; Yin, S.; Gong, Q.; Li, Y.; Liu, Z*., PEG-functionalized iron oxide nanoclusters loaded with chlorin e6 for targeted, NIR light induced, photodynamic therapy. Biomaterials ), ;
[38] Zhong, Y.; Wang, C.; Cheng, L.; Meng, F.; Zhong, Z.; Liu, Z*., Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells. Biomacromolecules ), ;
[37] He, L.; Feng, L.; Cheng, L.; Liu, Y.; Li, Z.; Peng, R.; Li, Y.; Guo, L.; Liu, Z*., Multilayer Dual-Polymer-Coated Upconversion Nanoparticles for Multimodal Imaging and Serum-Enhanced Gene Delivery. ACS Applied Materials & Interfaces ), (IF=5.008, Citation=0).
[36] Liao, F.; Cheng, L.; Li, J.; Shao, M.*; Wang, Z.; Lee, S.-T., An Effective Oxide Shell-protected Surface-enhanced Raman Scattering (SERS) Substrates: the Easy Route to Ag@AgxO- Silicon Nanowire Films via Surface Doping. J. Mater. Chem. 28-1632.
[35] Cheng, L.; Yang, K.; Li, Y.; Zeng, X.; Shao, M.; Lee, S.-T.; Liu, Z*., Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy. Biomaterials 15-2222.
[34] Cheng, L.; Yang, K.; Chen, Q.; Liu, Z*., Organic nanoparticles for ultra-effective in vivo near-infrared photothermal therapy of cancer. ACS Nano 05-5613
[33] Cheng, L.; Shao, M*.; Yin, K.; Liu, Z*., AgI Modified Silicon Nanowires: Synthesis, Characterization and Properties of Ionic Conductivity and Surface-Enhanced Raman Scattering. CrystEngComm 1-604.
[32] Wang, X.; Wang, C.; Cheng, L.; Lee, S.-T.; Liu, Z*., Noble Metal Coated Single-Walled Carbon Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and Photothermal Therapy. J. Am. Chem. Soc ,
[31] Wang, C.; Cheng, L.; Xu, H.; Liu, Z*., Towards whole-body imaging at the single cell level using ultra-sensitive stem cell labeling with oligo-arginine modified upconversion nanoparticles. Biomaterials 72-4881.
[30] Shao, Q.; Que, R.; Shao*, M.; Cheng, L.; Lee, S.-T., Copper Nanoparticles Grafted on a Silicon Wafer and Their Excellent Surface-Enhanced Raman Scattering. Adv. Funct. Mater 67-2070
[29] Xu, H.; Cheng, L.; Wang, C.; Liu, Z*., Upconversion nanoparticles for biological imaging. J. Nanosci. Lett. -15.
[28] Yang, K.; Xu, H.; Cheng, L.; Sun, C.; Wang, J.; Liu, Z*., In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles. Adv. Mater. 86-5592.
[27] Ma, X.; Tao, H.; Yang, K.; Feng, L.; Cheng, L.; Shi, X.; Yonggang, L.; Guo, L.; Liu, Z*., A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging. Nano Res. 9-212
[26] Cheng, L.; Yang, K.; Li, Y.; Chen, J.; Wang, C.; Shao, M.; Lee, S.-T.; Liu, Z*., Facile preparation of multifunctional upconversion nanoprobes for multi-modal imaging and dual-targeted photothermal therapy. Angew. Chem. Int. Ed 85-7390.
[25] Cheng, L.; Yang, K.; Lu, X.; Shao, M.; Liu, Z*., In vivo Pharmacokinetics, Long-term Biodistribution and Toxicology Study of Functionalized Upconversion Nanoparticles in Mice. Nanomedicine 27-1340
[24] Cheng, L.; Yang, K.; Shao, M.; Lee, S.-T.; Liu, Z*., Multicolor In Vivo Imaging of Upconversion Nanoparticles with Emissions Tuned by Luminescence Resonance Energy Transfer. J. Phys. Chem. C ,
[23] Xu, H.; Cheng, L.; Wang, C.; Ma, X.; Li, Y.; Liu, Z*., Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. Biomaterials 64-9373
[22] Wang, C.; Cheng, L.; Liu, Z*., Drug Delivery with Upconversion Nanoparticles for Multi-Functional Targeted Cancer Cell Imaging and Therapy. Biomaterials 10-1120.
[21] Wang, C.; Cheng, L.; Liu, Z*., Upconversion nanoparticles for potential cancer theranostics. Therapeutic Delivery 35-1239.
[20] Liu, L.; Shao, M*.; Cheng, L.; Zhuo, S.; Que, R.; Lee, S. T., Edge-enhanced Raman scattering effect from Au deposited nanoedge array. Appl. Phys. Lett. 3114-3
[19] Zhou, Q.; Shao, M*.; Que, R.; Cheng, L.; Zhuo, S.; Tong, Y.; Lee, S.-T., Silver vanadate nanoribbons: A label-free bioindicator in the conversion between human serum transferrin and apotransferrin via surface-enhanced Raman scattering. Appl. Phys. Lett. 3110-3
[18] Wang, C; Tao, H.Q; Cheng, L.; Liu, Z.*, Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles. Biomaterials 45-6154
[17] Cheng, L.; Yang, K.; Zhang, S.; Shao, M.; Lee, S., Liu, Z.*,Highly-sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles. Nano Res 2-732.
[16] Cheng, L.; Shao, M.-W*.; Chen, D.; Ma, D. D. D.; Lee, S.-T., SnO2 nanowires with strong yellow emission and their application in photoswitches. CrystEngComm 36-1539
[15] Cheng, L.; Shao, M*.; Zhang, M.; Ma, D. D. D., An Ultrasensitive Method to Detect Dopamine From Single Mouse Brain Cell: Surface-Enhanced Raman Scattering on Ag Nanoparticles From Beta-Silver Vanadate and Copper. Sci. Adv. Mater. 6-389.
[14] Cheng, L.; Shao, M*.; Chen, D.; Zhang, Y., Preparation, characterization, and electrochemical application of mesoporous copper oxide. Materials Research Bulletin 5-239
[13] Zhuo, S.-J.; Shao, M.-W*.; Cheng, L.; Que, R.-H.; Ma, D. D. D.; Lee, S.-T., Silver/silicon nanostructure for surface-enhanced fluorescence of Ln(3+) (Ln=Nd, Ho, and Er). J. Appl. Phys. 4305-3.
[12] Zhuo, S.; Shao, M*; Cheng, L.; Que, R.; Zhuo, S.; Ma, D. D. D.; Lee, S.-T., Surface-enhanced fluorescence of praseodymium ions Pr3+on silver/silicon nanostructure. Appl. Phys. Lett. 3108-3.
[11] Shao, M*.; Cheng, L.; Zhang, X.; Duo, D. D.; Lee, s., Excellent Photocatalysis of HF-Treated Silicon Nanowires. J. Am. Chem. Soc , .
[10] Shao, M*.; Cheng, L.; Zhang, M.; Ma, D. D. D.; Zapien, J. A.; Lee, S.-t.; Zhang, X., Nitrogen-doped silicon nanowires: Synthesis and their blue cathodoluminescence and photoluminescence. Appl. Phys. Lett. 3110-3.
[9] Cheng, L.; Shao, M*.; Wang, X.; Hu, H., Single-Crystalline Molybdenum Trioxide Nanoribbons: Photocatalytic, Photoconductive, and Electrochemical Properties. Chem. Eur. J. 10-2316.
[8] Cheng, L.; Shao, Q.; Shao, M*.; Wei, X.; Wu, Z., Photoswitches of One-Dimensional Ag2MO4 (M) Cr, Mo, and W). J. Phys. Chem. B ,
[7] Cheng, L.; Shao, M*.; Chen, D.; Wei, X.; Wang, F.; Hua, J., High-yield fabrication of t-Se nanowires via hydrothermal method and their photoconductivity. J Mater Sci: Mater Electron 09-1213.
[6] Wang, F.; Shao, M.*; Cheng, L.; Chen, D.; Fu, Y.; Ma, D. D. D., Si/Pd nanostructure with high catalytic activity in degradation of eosin Y. Materials Research Bulletion 6-129.
[5] Shao, M.-W.*; Fu, Y.; Cheng, L.; Wang, X.-H.; Ma, D.-D.-D.; Lee, S.-T., Fabrication and application of long silicon nanowire yarns. J Mater Sci: Mater Electron 00-1202.
[4] Chen, D.-Y.; Shao, M.-W.*; Cheng, L.; Wang, X.-H.; Ma, D. D.-d., Strong and stable blue photoluminescence: The peapodlike SiOx@Al2O3 heterostructure. Appl. Phys. Lett. 3101-3.
[3] Wang, F.; Shao, M.*; Cheng, L.; Hua, J.; Wei, X., The synthesis of monoclinic bismuth vanadate nanoribbons and studies of photoconductive, photoresponse, and photocatalytic properties. Materials Research Bulletion 87-1691.
[2] Hua, J.; Shao, M W*; Cheng, L.; Wang, X.H.; Fu, Y. Ma, D.D, The fabricationofsilver-modifiedsiliconnanowiresandtheirexcellent catalysis in the decomposition of fluoresce insodium. J. Phys. Chem. Solid 2-196.
[1] Wang, S.; Shao, M.-W.*; Shao, G.; Wang, H.; Cheng, L., Room temperature and long-lasting blue phosphorescence of Cr-doped a-Al2O3 nanowires. Chem. Phys. Lett. , 200-204.